Membrane Restraint of Estrogen Receptor α Enhances Estrogen-Dependent Nuclear Localization and Genomic Function
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چکیده
منابع مشابه
Estrogen-related Receptor β Reduces the Subnuclear Mobility of Estrogen Receptor α and Suppresses Estrogen-dependent Cellular Function.
Estrogen-related receptor (ERR) is a member of the nuclear receptor superfamily that has strong homology with estrogen receptor (ER) α. ERR has three subtypes (α, β, and γ) expressed in estrogen-sensitive organs, including ovary, breast, and brain. No endogenous ligands of ERRs have been identified, but these receptors share a common DNA element with ERα and control estrogen-mediated gene trans...
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*Department of Biology, University Roma Tre, I-00146 Rome, Italy; †Interdepartmental Laboratory for Electron Microscopy, University Roma Tre, I-00146 Rome, Italy; ‡National Institute for Infectious Diseases Istituto di Ricovero e Cura a Carattere Scientifico Lazzaro Spallanzani, I-00149 Rome, Italy; §Department of Chemistry, Chemical Engineering, and Materials, University of L’Aquila, I-67100 L...
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Over the decades, our understanding of estrogen receptor (ER) function has evolved. Today we are confronted by at least two nuclear ERs, ERα and ERβ, and a number of putative membrane ERs, including ERα, ERβ, ER-X, GPR30 and Gq-mER. These receptors all bind estrogens or at least estrogenic compounds and activate intracellular signaling pathways. In some cases, a well-defined pharmacology and ph...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2004
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2003-0262